25,26-Dihydroxyvitamin D3是维生素D3代谢物。
25,26-Dihydroxyvitamin D3产品描述：25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity. IC50 value: Target: VD metabolite The biological activity of synthetic 24,25 ａnd 25,26 diOHD3 was studied in vitamin D-deficient rats. The purpose of this study was to investigate the influence of small doses of both metabolites (0.125-0.250 mug) upon intestinal calcium transport ａnd bone calcium mobilization. Both metabolites were able to increase calcium absorption in rats maintained on a calcium-deficient diet, but failed to do it in rats on a normal calcium diet. Bilateral nephrectomy suppressed this effect. The "bone calcium mobilization" of both derivatives was measured in vitamin D ａnd calcium- or phosphorus-deprived rats after one intravenous dose. When serum calcium was initially low, 24,25 ａnd 25,26 diOHD3 increased serum calcium moderately, but the increment was only significant with 24,25 diOHD3.
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Purity:96.34%
MWt:416.64
Formula:C27H44O3
SMILES:C[C@@H]([C@H]1CC[C@@]2([H])/C(CCC[C@]12C)=C/C=C3C(CC[C@H](O)C\3)=C)CCCC(O)(C)CO
Pathway:Vitamin D Related;
Mechanisms:VD/VDR;
Research Area:Others
原创作者：MedChemExpress
