PAβN (dihydrochloride)产品描述：PAβN dihydrochloride (MC-207110 dihydrochloride)是外排泵的抑制剂。
PAβN (dihydrochloride)产品描述：PAβN dihydrochloride (MC-207110 dihydrochloride) is an
efflux pump inhibitor.
In Vitro: PAβN increases the susceptibilities of the three pump-overexpressing mutants of
P. aeruginosa to levofloxacin 64-fold. PAβN also potentiates the activity of levofloxacin against strain PAM2391 containing plasmid pAGH97 with the mexXY genes ａnd against wild-type strain PAM1020. PAβN has an effect on susceptibilities to other antibiotics that are substrates of efflux pumps. PAβN increases levels of accumulation of efflux pump substrates inside the cell. It enhances the activity of levofloxacin against clinical isolates of
P. aeruginosa[1]. PAβN reduces the MICs in nine ciprofloxacin-resistant isolates, ａnd in four of these, PAβN increases the susceptibility by twofold. Moreover, PAβN restores ciprofloxacin susceptibility in five of the ciprofloxacin-resistant isolates. In addition, clear effects of NMP on the ciprofloxacin MICs are seen for 20 of these ciprofloxacin-resistant isolates
[2]. PAβN permeabilizes bacterial membranes in a concentration-dependent manner at levels below those typically used in combination studies, ａnd this additional mode of action should be considered when using PAβN as a control for efflux studies
[3].
研究领域：
Epigenetics靶点：
Epigenetic Reader Domain相关产品：
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EPZ-6438 |
GSK126 |
OTX-015 |
GSK 525762A |
BI 2536 |
GSK343 |
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UNC1999 |
KU-57788 |
I-BET151 |
ARV-825 |
SGC-CBP30 |
Mivebresib |
RVX-208 |
Alternative_Names:MC-207,110 dihydrochloride;Phe-Arg-β-naphthylamide dihydrochloride
MWt:519.47
Formula:C25H32Cl2N6O2
SMILES:O=C([C@H](CCCNC(N)=N)NC([C@H](CC1=CC=CC=C1)N)=O)NC2=CC(C=CC=C3)=C3C=C2.Cl.Cl
Research_Area:Infection
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原创作者：MedChemExpress
