发布时间:2021/8/26 15:44:01 阅读人数:480
研究显示,斑马鱼和人类基因组的同源性高达 70% 以上。斑马鱼的基因组与人类疾病相关基因的相似性高达 80%。和人相比,斑马鱼的生理机能非常保守 (有时候比啮齿类动物更保守),如心脏电生理学。
此外,斑马鱼和人类一样,会自然的产生癌变,且大多数致癌基因和肿瘤抑制基因在进化上是保守的。由于斑马鱼的相对透明性,可用于识别癌变和肿瘤进展的研究。与哺乳动物不同,斑马鱼的胚胎是在外部发育的。斑马鱼还有着远优于哺乳动物的繁殖能力,性成熟的雌性斑马鱼,平均每条鱼 1-2 天可产卵几十到几百颗。
青鳉个体小、繁殖快、近交品系多、突变体多,有完整的基因组序列,与大多数鱼类不同,青鳉具有二倍体染色体结构,是拥有雄性性别决定基因和雌性决定基因的脊椎动物。多种干细胞系的建立为研究基因功能所需的细胞生物学研究提供了良好的平台。ZFN 和 TALENs,尤其是 CRISP Cas9 技术在青鳉中均已成功应用。越来越多的学者以青鳉为模式物种进行生殖细胞发育等功能研究。
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原创作者:MedChemExpress
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