TOFA产品描述：TOFA （RMI14514;MDL14514）是乙酰辅酶A羧化酶-α （
ACCA ）的变构抑制剂。
TOFA产品描述：TOFA （RMI14514;MDL14514） is an allosteric inhibitor of acetyl-CoA carboxylase-α （
ACCA ）.
In Vitro: TOFA （5-tetradecyloxy-2-furoic acid） is cytotoxic to lung cancer cells NCI-H460 ａnd colon carcinoma cells HCT-8 ａnd HCT-15, with an IC
50 at approximately 5.0, 5.0, ａnd 4.5 μg/mL, respectively. TOFA at 1.0–20.0 μg/mL effectively blocks fatty acid synthesis ａnd induces cell death in a dose-dependent manner
[1]. TOFA is found to be cytotoxic to COC1 ａnd COC1/DDP cells with IC
50 values of ~26.1 ａnd 11.6 µg/mL, respectively. TOFA inhibits the proliferation of the cancer cells examined in a time ａnd dose dependent manner, arrests the cells in the G0/G1 cell cycle phase ａnd induces apoptosis
[2]. Acetyl-CoA-carboxylase-α （ACCA） is a key enzyme in the regulation of fatty acids synthesis. Inhibition of ACCA by TOFA decreases fatty acid synthesis ａnd induces caspase activation ａnd cell death in most PCa cell lines
[3].
In Vivo: TOFA inhibits COC1/DDP cell growth in ovarian tumor mouse xenografts. The tumor growth rate is signifi¬cantly inhibited by TOFA compared with the DMSO treated control mice （1649±356.3 vs. 5128±390.4 mm
3. No toxicity is observed in the heart, liver, spleen, lung, kidney ａnd intestinal tissues. By inhibiting ACC, TOFA may be a promising small molecule agent for ovarian cancer therapy
[2].
研究领域：
Immunology/Inflammation靶点：
Salt-inducible Kinase （SIK）相关产品：
HG-9-91-01 |
Alternative_Names:RMI14514;MDL14514
MWt:324.45
Formula:C19H32O4
SMILES:O=C（C1=CC=C（OCCCCCCCCCCCCCC）O1）O
Research_Area:Cancer
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