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Guaiacol

CAS No. : 90-05-1

MCE 站：Guaiacol

产品活性：Guaiacol 是一种从愈创木树脂分离的酚类化合物，抑制 LPS 刺激的 COX-2 表达和 NF-κB 激活。具有抗炎活性。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：COX  |  NF-κB  |  Endogenous Metabolite

In Vitro: Guaiacol inhibits LPS-stimulated nuclear factor kappa B (NF-κB) activation and cyclooxygenase (COX)-2 gene expression in cells of the RAW 264.7 murine macrophage cell line. Phenolic compounds such as Phenol, Eugenol, Guaiacol and Vanillin inhibit sheep vesicular gland prostaglandin cyclooxygenase, as indicated by their 50% inhibition concentrations, which decline in the following order: Phenol (1600 μM) > Vanillin (>500 μM) > Guaiacol (72 μM) > Eugenol (12 μM).

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