型号:_Huazhongilexone
产品价格:电议      采购度:1852      原产地:中国大陆
发布时间:2020/7/14 12:04:25 所属地区:上海 上海市
简要描述:
Eriodictyol 是从中草药中得到的黄酮类,具有抗氧化、抗炎的功效。Eriodictyol 能够诱导 Nrf2 信号通路。
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CAS No. : 552-58-9
MCE 站:Eriodictyol
产品活性:Eriodictyol 是从中草药中得到的黄酮类,具有抗氧化、抗炎的功效。Eriodictyol 能够诱导 Nrf2 信号通路。
研究领域:Metabolic Enzyme/Protease | NF-κB
作用靶点:Endogenous Metabolite | Keap1-Nrf2
In Vitro: Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol (20, 40, 80 μM) protects primary cultured cortical neurons against Aβ25-35-induced cytotoxicity and cell apoptosis via the Nrf2/ARE pathway. Eriodictyol (80 μM) induces nuclear expression of Nrf2 and the expression of ARE-regulated genes in primary cultured cortical neurons.
In Vivo: Eriodictyol shows protective effect against LPS-induced acute lung injury (ALI). Eriodictyol (30 mg/kg, p.o.) decreases the production of inflammatory cytokines, elevates survival rate, and decreases oxidative stress levels in LPS-induced ALI mice. Eriodictyol inhibits MPO activity and inflammatory neutrophil accumulation in the lung tissues. Eriodictyol treatment also enhances Trx1 expression by upregulating the Nrf2 expression in lung tissues.
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更新时间:2024/1/2 10:11:10
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