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Zinc Protoporphyrin

CAS No. : 15442-64-5

MCE 站：Zinc Protoporphyrin

产品活性：Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) 是一种具有口服活性的，竞争性的血红素加氧酶-1 (HO-1) 抑制剂，显着减弱间苯三酚 (PG) 对 H₂O₂ 的保护作用。Zinc Protoporphyrin 可用作个体孕妇和儿童缺铁的筛查标志物，也用于评估人群铁状态与血红蛋白浓度的组合。Zinc Protoporphyrin 具有抗癌活性。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Reactive Oxygen Species  |  Endogenous Metabolite  |  Apoptosis

In Vitro: Zinc Protoporphyrin (Zn(II)-protoporphyrin IX; 5 μM; 72 hours) causes the fraction of late apoptotic and necrotic cells increasing from 10.9% in controls to 30.4% after 72 h.
Zinc Protoporphyrin (1.25-40 μM; 48 or 72 hours) exerts cystostatic/cytotoxic effects against tumor cells.
Zinc Protoporphyrin (2.5, 5 μM; 48 or 72 hours) results in dose- and time-dependent reduction of cells in G1 phase of the cell cycle.
Zinc Protoporphyrin (1.25-40 μM; 48 hours) leads to accumulation of cleaved (active) caspase-3.

In Vivo: Zinc Protoporphyrin (12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.; from day 7 to 19) exerts dose-dependent antitumor effects manifested by the retardation of tumor growth.

相关产品：Human Endogenous Metabolite Compound Library  |  Apoptosis Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  NF-κB Signaling Compound Library  |  Orally Active Compound Library  |  Oxygen Sensing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Ferroptosis Compound Library  |  Anti-Cancer Compound Library  |  Metabolism/Protease Compound Library  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Pyroptosis Compound Library  |  Rapamycin  |  MG-132  |  3-Methyladenine  |  LY294002  |  Actinomycin D  |  Mitomycin C  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Paclitaxel  |  Y-27632 dihydrochloride  |  SP600125  |  Sorafenib  |  Angiotensin II human  |  MK-2206 dihydrochloride  |  5-Fluorouracil  |  H2DCFDA  |  Trametinib  |  Bortezomib  |  Tamoxifen  |  Gemcitabine  |  Pexidartinib  |  Acetylcysteine  |  Decitabine  |  BAY 11-7082  |  2-Deoxy-D-glucose  |  Temozolomide  |  Docetaxel  |  Dasatinib  |  Verteporfin

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