型号:_盐酸阿柔比星
产品价格:电议      采购度:1885      原产地:中国大陆
发布时间:2020/7/14 12:22:40 所属地区:上海 上海市
简要描述:
Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子,是个发现对 20S 蛋白酶体 (20S proteasome) 的CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。同时也是 拓扑异构酶 I 和 II (topoisomerase I and II) 的双抑制剂。是一种有效治疗血癌和实体肿瘤的蒽环类化疗药物。
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CAS No. : 75443-99-1
MCE 站:Aclacinomycin A hydrochloride
产品活性:Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子,是个发现对 20S 蛋白酶体 (20S proteasome) 的CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。同时也是 拓扑异构酶 I 和 II (topoisomerase I and II) 的双抑制剂。是一种有效治疗血癌和实体肿瘤的蒽环类化疗药物。
研究领域:Metabolic Enzyme/Protease | Cell Cycle/DNA Damage
作用靶点:Proteasome | Topoisomerase
In Vitro: Aclacinomycin A could efficiently enter living cells and emit fluorescence in situ. Aclacinomycin A (10 μM for 15 min) is sufficient for clear detection of fluorescence in most of the cultured cells. Aclacinomycin A treatment (10 μM Acla for 15 min) results in approximately 20% dead (or nearly dead) cells.
Aclacinomycin A (Aclarubicin) effectively induces incorporation of exon 7 into SMN2 transcripts from the endogenous gene in type I SMA fibroblasts as well as into transcripts from a SMN2 minigene in the motor neuron cell line NSC34 .
In Vivo: Aclacinomycin A is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD50 (76.5 mg/kg) is about twice the iv LD50 (35.6 mg/kg) in mice.
Aclacinomycin A (0.75-6 mg/kg, ip daily) dose-dependently exhibits tumor growth in mice-based Leukemia P-388 model.
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更新时间:2024/1/2 10:11:10
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