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1V209

CAS No. : 1062444-54-5

MCE 站：1V209

产品活性：1V209 (TLR7 agonist T7) 是 Toll-like receptor 7 (TLR7) 激动剂，具有抗肿瘤作用。1V209 可与各种多糖缀合，以改善其水溶性，增强功效并保持低毒性。

研究领域：Immunology/Inflammation

作用靶点：Toll-like Receptor (TLR)

In Vitro: 1V209 (0.1-10 μM) treatment significantly stimulates TNFα production in RAW246.7 cells.
1V209 (18 hours) treatment increases IL-6 production comparain bone marrow derived dendritic cells.

In Vivo: The intravenous (IV) administration of the formulation to mice bearing 4T1 breast cancer tumors results in nanoparticle accumulation in tumors, reduction in primary tumor growth, and inhibition of lung metastases, as compared to saline-treated animals. Mice administered 1V209 experience significantly increases plasma levels of proinflammatory cytokines IL-6, IP-10, and MCP-1 at 2 h following IV administration.

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