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Evogliptin tartrate

CAS No. : 1222102-51-3

MCE 站：Evogliptin tartrate

产品活性：Evogliptin tartrate 是一种高效、口服有效、选择性的 DPP-4 抑制剂，具有抗糖尿病活性。Evogliptin tartrate 具有靶向动脉炎症治疗动脉粥样硬化的潜力。

研究领域：Metabolic Enzyme/Protease

作用靶点：Dipeptidyl Peptidase

In Vitro: Evogliptin tartrate significantly inhibits the TNF-α-mediated induction of ICAM-1 and VCAM-1 expression in a concentration-dependent manner (IC₅₀ = 0.30 and 0.25 μM, respectively).
Evogliptin tartrate inhibits the TNF-α-mediated transcriptional activation of ICAM-1 and VCAM-1.
Evogliptin tartrate inhibits inflammatory responses via suppression of adhesion molecules induced by TNF-α. And TNF-α-mediated activation of NF-κB is ameliorated by evogliptin via the interaction of NF-κB with SIRT1.

In Vivo: Evogliptin tartrate (37.5-150 mg/kg; p.o.; daily; for 12 weeks) reduces the high-fat diet-induced atherosclerotic plaque area in the ApoE^?/? mouse model.
Evogliptin tartrate inhibits the formation of atherosclerotic lesions by reducing vasoinflammation and increases plaque stability.

相关产品：Talabostat mesylate  |  Sitagliptin  |  Puromycin aminonucleoside  |  Vildagliptin  |  AZD7986  |  Linagliptin  |  Saxagliptin  |  Teneligliptin  |  Gemigliptin  |  Omarigliptin  |  Anagliptin  |  Alogliptin Benzoate  |  Diprotin A TFA  |  Trelagliptin  |  DBPR108  |  DPP-IV-IN-2  |  Nateglinide  |  1G244  |  Dutogliptin  |  Gosogliptin  |  Prodipine hydrochloride  |  Retagliptin Phosphate  |  Saikogenin A  |  UAMC00039 dihydrochloride  |  Alogliptin (13CD3)

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