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Lefamulin acetate

CAS No. : 1350636-82-6

MCE 站：Lefamulin acetate

产品活性：Lefamulin acetate (BC-3781 acetate) 是一种口服活性抗生素，用于 community-acquired bacterial pneumonia (CABP) 治疗。Lefamulin acetate (BC-3781 acetate) 是种用于人体细菌感染的全身治疗的半合成截短侧耳素。Lefamulin acetate (BC-3781 acetate) 通过与 50S 细菌核糖体的肽基转移酶 peptidyl transferase 中心结合来抑制蛋白质合成，从而阻止了转移RNA与肽转移的结合。

研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

In Vitro: Lefamulin acetate (BC-3781 acetate) has activity against the resistant gram-postive organisms, including taphylococcus aureus (MRSA) (MIC₅₀=0.12 μg/ml; MIC₉₀=0.25 μg/ml); β-Hemolytic strepococcus (MIC₅₀=0.03 μg/ml; MIC₉₀=0.03 μg/ml); Viridans group Streptococcus (MIC₅₀=0.12 μg/ml; MIC₉₀=0.5 μg/ml), Enterocossus faecium (MIC₅₀=0.12 μg/ml; MIC₉₀=4 μg/ml), Streptococcus pneumonia (MIC₅₀=0.12 μg/ml; MIC₉₀=0.25 μg/ml).
Lefamulin has activity against gram-negative organisms, including Haemophilus influenza (MIC₅₀=1 μg/ml; MIC₉₀=0.12 μg/ml) and Moraxella cotarrhali (MIC₅₀=2 μg/ml; MIC₉₀=0.25 μg/ml).

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