MCE 的所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。

L-Buthionine-(S,R)-sulfoximine

CAS No. : 83730-53-4

MCE 站：L-Buthionine-(S,R)-sulfoximine

产品活性：L-Buthionine-(S,R)-sulfoximine 是一种具有细胞渗透性的、有效的、快速起效的、不可逆的 G-谷氨酸半胱氨酸合成酶 (γ-glutamylcysteine synthetase) 抑制剂，可降低细胞内谷胱甘肽的水平，其对黑色素瘤、乳腺卵巢癌标本的 IC₅₀ 值分别为1.9 μM、8.6 μM 和29 μM。

研究领域：Apoptosis

作用靶点：Ferroptosis

In Vitro: L-Buthionine-(S,R)-sulfoximine (BSO: 50 μM) treatment for 48 hr results in a 95% decrease in ZAZ and M14 melanoma cell line GSH levels, and a 60% decrease in GST enzyme activity. GST-π protein and mRNA levels are significantly reduced in both cell lines. L-Buthionine-(S,R)-sulfoximine (BSO) induces oxidative stress in a cell by irreversibly inhibiting g-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione (GSH).

In Vivo: The average number of eye-spots (mean±SEM) is 5.36±0.29 (n=46), 7.79±0.45 (n=34) and 8.78±0.61 (n=32) in untreated controls, 2 mM L-Buthionine-(S,R)-sulfoximine (BSO) and 20 mM BSO treated mice, respectively. The 2 mM BSO treatment results in ~30% more eye-spots, and the 20 mM treatment results in 40% more eye-spots compared with untreated mice. It is showed that BSO causes an elevated frequency of DNA deletions during mouse development. BSO treatment reduced GSH concentration in mouse fetuses by 55% and 70% at 2 mM and 20 mM BSO doses, respectively, compared to untreated mice. Co-treatment with 2 mM BSO and 20 mM NAC depleted GSH to a similar extent as 2 mM BSO, consistent with the function of BSO to inhibit the g-GCS enzyme indispensable for GSH synthesis. Like GSH, cysteine levels dropped following BSO treatment.

相关产品：Apoptosis Compound Library  |  Covalent Screening Library Plus  |  Covalent Screening Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Anti-Cancer Compound Library  |  Bioactive Compound Library Plus  |  Cycloheximide  |  Cisplatin  |  Erastin  |  SP600125  |  Sorafenib  |  Ferrostatin-1  |  Acetylcysteine  |  Deferoxamine mesylate  |  ML385  |  Necrostatin-1  |  RSL3  |  SB 202190  |  Rosiglitazone  |  Lapatinib  |  Curcumin  |  Roxadustat  |  (-)-Epigallocatechin Gallate  |  U-73122  |  Simvastatin  |  Bardoxolone (methyl)  |  Hemin  |  TBHQ  |  Liproxstatin-1  |  Pifithrin-α hydrobromide  |  Lovastatin  |  NADPH tetrasodium salt  |  Atorvastatin hemicalcium salt  |  Troglitazone

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。