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SQ22536

CAS No. : 17318-31-9

MCE 站：SQ22536

产品活性：SQ22536 是一种有效的腺苷酸环化酶 (AC) 抑制剂。

研究领域：GPCR/G Protein

作用靶点：Adenylate Cyclase

In Vitro: SQ22536 (SQ22,536) effectively inhibits the effect of forskolin with respective IC₅₀ values of 5 μM.Preincubation with graded concentrations of SQ22536 reveals that both SQ22536 effectively inhibits PACAP-induced reporter gene activation with approximate IC₅₀ value of 5 μM. SQ22536 more potently inhibits forskolin-induced Elk activation (IC₅₀=10 μM) than 8-Br-cAMP-induced Elk activation (IC₅₀=170 μM). Most notably, there are substantial differences in the reported potencies of SQ22536 to inhibit the activities of recombinant AC5 and AC6, with respective IC₅₀ values of 2 μM and 360 μM. At a greater concentration (500 μM), SQ22536 significantly inhibits neurite elongation due to either forskolin or 8-Br-cAMP.

相关产品：Nucleotide Compound Library  |  Natural Product Like Compound Library  |  GPCR/G Protein Compound Library  |  Bioactive Compound Library Plus  |  Forskolin  |  α-Melanocyte-Stimulating Hormone (MSH), amide  |  NKH477  |  ST034307  |  CB-7921220  |  2´,5´-Dideoxyadenosine  |  NB001  |  NKY80  |  TIP 39, Tuberoinfundibular Neuropeptide  |  LRE1  |  Small Cardioactive Peptide B SCPB

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