MCE 的所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。

MBC-11 trisodium

CAS No. : 387877-45-4

MCE 站：MBC-11 trisodium

产品活性：MBC-11 trisodium 是一线的、骨靶向双膦酸乙酯与抗代谢物阿糖胞苷 (Ara-C) 共价结合的偶联物。具有治疗肿瘤性骨病 (TIBD) 的潜力。

研究领域：Others

作用靶点：Others

In Vitro: MBC-11 shows similar activity profiles and significantly inhibits growth of all three cell lines between 10^-8 and 10^-4 M. MBC-11 decreases KAS-6/1 cell growth from approximately 56% at 10^-8 M to 6% at 10^-5 M

In Vivo: MBC-11 (0.04 μg/day, s.c.) has a lower incidence of bone metastases of 40% compared to those treated with PBS (90%) or 0.04 μg/day zoledronate (100%). MBC-11 also significantly decreases bone tumor burden compared to PBS- or zoledronate-treated mice.
Weight gained in mice treated with up to 500 μg/day of MBC-11 is similar to the PBS treated group.
These results demonstrate that MBC-11 decreases bone tumor burden, maintains bone structure, and may increase overall survival, warranting further investigation as a treatment for tumor-induced bone disease (TIBD).

相关产品：SBE-β-CD  |  PEG300  |  Corn oil  |  D-Lin-MC3-DMA  |  Tween 80  |  Solutol HS-15  |  Auxinole  |  DTT  |  JC-1  |  Monocrotaline  |  CFSE  |  DAPI dihydrochloride  |  Thiazolyl Blue  |  Nile Red  |  D-Luciferin potassium salt  |  (2-Hydroxypropyl)-β-cyclodextrin  |  Digitonin  |  Methyl-β-cyclodextrin  |  ISA-2011B  |  IPTG  |  Calcein-AM  |  Propidium Iodide  |  Tocofersolan  |  Diphenylterazine  |  O-Propargyl-Puromycin  |  FITC  |  FLAG peptide  |  Cholera toxin

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。