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MM 07

CAS No. : 1876450-21-3

MCE 站：MM 07

产品活性：MM 07 是一种有偏倚性的 apelin 受体 (apelin receptor) 激动剂，在 CHO-K 细胞中的 K_D 值为 300 nM，在人心脏中的 K_D 值为 172 nM。

研究领域：Others

作用靶点：Others

In Vitro: MM 07 competes with nanomolar affinities for binding of [Glp⁶⁵,Nle⁷⁵,Tyr⁷⁷] [¹²⁵I]apelin-13 to human apelin receptors in CHO-K1 cells (K_D, 300 nM) and human heart (K_D, 172 nM, n=3).

In Vivo: MM 07 causes a dose-dependent increase in cardiac output, and although there is a decrease in vascular resistance, this is without corresponding effects on BP. Administration of SNAP produces a profound fall in BP in both [Pyr¹]apelin-13 and MM 07-treated groups; however, although cardiac output is significantly increased in response to SNAP in the MM 07 group, it is significantly reduced in the [Pyr¹]apelin-13 group. Neither peptide causes a significant change in heart rate, respiratory rate, or temperature. Both [Pyr¹]apelin 13 and MM 07 increases peak velocity above basal levels.

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