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GSK3145095

CAS No. : 1622849-43-7

MCE 站：GSK3145095

产品活性：GSK3145095 是一种 RIP1 激酶抑制剂，其 IC₅₀ 值为 6.3 nM 。

研究领域：Apoptosis

作用靶点：RIP kinase

In Vitro: GSK3145095 potently blocks the TNF response as shown by determination of overall cell viability as measured by cellular ATP levels (IC₅₀ = 1.6 nM), cell death as measured by LDH release (IC₅₀ = 0.5 nM) and RIP1-dependent inflammatory cytokine MIP-1β production, either as absolute levels for protein, or fold changes in mRNA expression (IC₅₀ = 0.4 nM) .

相关产品：Apoptosis Compound Library  |  Drug Repurposing Compound Library  |  Kinase Inhibitor Library  |  Clinical Compound Library  |  Clinical Compound Library Plus  |  Anti-COVID-19 Compound Library  |  Anti-Cancer Compound Library  |  Drug Repurposing Compound Library Plus  |  Bioactive Compound Library Plus  |  Necrostatin-1  |  GSK-872  |  GSK2982772  |  RIPA-56  |  Necrostatin 2 (racemate)  |  WEHI-345  |  GSK583  |  HS-1371  |  GSK2593074A  |  GSK2983559 active metabolite  |  GSK840  |  GSK-843  |  GSK547  |  GSK481  |  RIP2 kinase inhibitor 2  |  GSK963  |  RIPK1-IN-4  |  PK68  |  RIPK1-IN-7  |  Kongensin A  |  RIPK-IN-4  |  GNE684  |  PROTAC RIPK degrader-2  |  RIP1 kinase inhibitor 1  |  RIP2 kinase inhibitor 1  |  RIP2 Kinase Inhibitor 3

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