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PF-05231023

CAS No. : 1037589-69-7

MCE 站：PF-05231023

产品活性：PF-05231023 是一种长效的成纤维细胞生长因子21 (FGF21) 的类似物，是 FGF21 受体 的激动剂，有治疗 2 型糖尿病的潜能。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：FGFR

In Vitro: PF-05231023 is a long-acting fibroblast growth factor 21 (FGF21) analog.

In Vivo: Administration of native FGF21 and PF-05231023 (3?mg/kg or 10?mg/kg; subcutaneously twice a week for two weeks) improves glucose tolerance and liver insulin sensitivity in Zucker rats.
PF-05231023 (10 mg/kg; intraperitoneally injected) decreases retinal inflammation in diabetic mice. PF-05231023 reduces retinal IL-1β mRNA expression in Akita mice. PF-05231023 increases cone-specific arrestin4 expression in Akita mice. PF-05231023 restores photoreceptor morphology in Akita mice. PF-05231023 inhibits oxidative-stress-induced inflammation in photoreceptors. PF-05231023 decreases the variability of retinal NRF2 levels and shows a trend (non-significant) towards increased NRF2 levels in Akita mice.

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