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Radioprotectin-1

CAS No. : 1622006-09-0

MCE 站：Radioprotectin-1

产品活性：Radioprotectin-1 是一种高效特异性的溶血磷脂酸受体 2 (LPA₂) 激动剂，EC₅₀ 值为 25 nM (鼠源 LPA₂ 亚型) 。

研究领域：GPCR/G Protein

作用靶点：LPL Receptor

In Vitro: Radioprotectin-1 is a potent agonist of LPA₂ with an EC₅₀ of 5 pM and functions as a full agonist at the human ortholog of LPA₂.
Radioprotectin-1 (0-3 μM; 15 minutes) effectively reduces apoptosis induced by γ-irradiation and the radiomimetic drug Adriamycin in cells that expressed LPA₂ either endogenously or after transfection.

In Vivo: Radioprotectin-1 is a high-potency specific agonist of the murine LPA₂ GPCR .
Radioprotectin-1 (0.1 mg/kg, 0.3 mg/kg; s.c.; every 12 hours; for 3 days) decreases the mortality of C57BL/6 mice in models of the hematopoietic acute radiation syndromes (HE-ARS) and gastrointestinal acute radiation syndromes (GI-ARS) .
Radioprotectin-1 exerts its radioprotective and radiomitigative action through specific activation of the upregulated LPA₂ GPCR in Lgr5⁺stem cells.

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