型号:_NF-κB
产品价格:电议      采购度:1866      原产地:中国大陆
发布时间:2020/7/14 21:06:41 所属地区:上海 上海市
简要描述:
FW1256 是一种苯基类似物,也是一种缓释硫化氢 (H2S) 供体。FW1256 抑制 NF-κB 活性,并可诱导细胞凋亡 (apoptosis),具有有效的抗炎作用,并可用于癌症和心血管疾病的研究。
标签:fw1256
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CAS No. : 117089-08-4
MCE 站:FW1256
产品活性:FW1256 是一种苯基类似物,也是一种缓释硫化氢 (H2S) 供体。FW1256 抑制 NF-κB 活性,并可诱导细胞凋亡 (apoptosis),具有有效的抗炎作用,并可用于癌症和心血管疾病的研究。
In Vitro: FW1256 (200 ?M; 24.5 hours; AW264.7 cells) treatment significantly reduces IL-1β, COX-2 and iNOS mRNA and protein in LPS-stimulated RAW264.7 macrophages.
FW1256 (200 ?M; 24.5 hours; AW264.7 cells) treatment significantly reduces IL-1β, COX-2 and iNOS PROTE and protein in LPS-stimulated RAW264.7 macrophages.
FW1256 concentration dependently decreases TNF-α (IC50 of 61.2 ?M), IL-6 (IC50 of 11.7 ?M), PGE2 (IC50 of 25.5 ?M) and NO (IC50 of 34.6 ?M) generation in LPS-stimulated RAW264.7 macrophages and bone marrow-derived macrophages (BMDMs) (IC50s of 414.9 ?M, 300.2 ?M, 4 ?M and 9.5 ?M for TNF-α, IL-6, PGE2 and NO, respectively) .
FW1256 decreases NF-κB activation as evidenced by reduced cytosolic phospho-IκBα levels and reduces nuclear p65 levels in LPS-stimulated RAW264.7 macrophages treated with FW1256.
In Vivo: FW1256 (100 mg/kg; intraperitoneal injection; male C57BL/6 mice) treatment reduces IL-1β, TNFα, nitrate/nitrite and PGE2 levels in LPS-treated mice.
相关产品:Apoptosis Compound Library | Anti-Aging Compound Library | Antioxidants Compound Library | NF-κB Signaling Compound Library | Differentiation Inducing Compound Library | Oxygen Sensing Compound Library | Anti-Cardiovascular Disease Compound Library | Anti-Cancer Compound Library | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Pyroptosis Compound Library | MG-132 | LY294002 | Actinomycin D | Mitomycin C | Doxorubicin hydrochloride | Bafilomycin A1 | Paclitaxel | Y-27632 dihydrochloride | SP600125 | Sorafenib | Angiotensin II human | MK-2206 dihydrochloride | 5-Fluorouracil | Trametinib | Tamoxifen | Bortezomib | Gemcitabine | Pexidartinib | Acetylcysteine | Decitabine | BAY 11-7082 | 2-Deoxy-D-glucose | Docetaxel | Verteporfin | Temozolomide | Dasatinib | Ruxolitinib | Etoposide | DAPT
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更新时间:2024/1/2 10:11:33
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