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Ciliobrevin D

CAS No. : 1370554-01-0

MCE 站：Ciliobrevin D

产品活性：Ciliobrevin D 是一种细胞渗透性，可逆和特异性的 AAA + ATPase 运动细胞质动力蛋白抑制剂。Ciliobrevin D 抑制 Hedgehog (Hh) 信号和初级纤毛形成。Ciliobrevin D 在体外抑制依赖于动力蛋白的微管滑动和 ATPase 活性。

研究领域：Stem Cell/Wnt

作用靶点：Hedgehog

In Vitro: Cells treated with Ciliobrevin D exhibits abnormal (unfocused, multipolar, or collapsed) spindles with disrupted γ-tubulin localization in NIH-3T3 cells. Similar Ciliobrevin-induced spindle defects are observed in HeLa cells, although to a lesser extent. Ciliobrevin D addition also reversibly disrupts the pre-formed spindles of metaphase-arrested cells and reduces overall microtubule levels.
.Ciliobrevin D reversibly inhibits melanosome aggregation, but the non-cilia-disrupting derivative had no discernible effect at comparable doses. Ciliobrevin D similarly abrogates the movement of peroxisomes in Drosophila S2 cells.

In Vivo: Knockdown of Dync1h1 or inactivation of dynein 1 by Ciliobrevin D in the testis in vivo perturbs spermatogenesis. Knockdown of Dync1h1 or the use of Ciliobrevin D to inactivate dynein 1 in the testis in vivo perturbs MT organization through changes in the spatial expression of EB1, perturbs F-actin organization, and perturbs distribution of adhesion protein complexes at the BTB, leading to a loss of BTB integrity. F-actin disorganization in the seminiferous epithelium following Dync1h1 knockdown or dynein 1 inactivation by Ciliobrevin D is mediated by changes in the spatiotemporal expression of actin regulatory proteins Arp3 and Eps8.

相关产品：Anti-Aging Compound Library  |  Differentiation Inducing Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Bioactive Compound Library Plus  |  Wnt/Hedgehog/Notch Compound Library  |  Vismodegib  |  Cyclopamine  |  Itraconazole  |  Ciliobrevin A  |  SANT-1  |  JK184  |  RU-SKI 43 hydrochloride  |  MK-4101  |  Jervine  |  Neurodazine  |  CUR61414  |  Dynarrestin  |  Hh-Ag1.5

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