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SAG hydrochloride

CAS No. : 2095432-58-7

MCE 站：SAG hydrochloride

产品活性：SAG (hydrochloride) 是一种有效的 Smo 受体激动剂，能够活化 Hedgehog 信号通路，K_d 值为 59 nM。

研究领域：Stem Cell/Wnt

作用靶点：Smo

In Vitro: SAG (hydrochloride) acts downstream of Ptch1 in the Hh pathway and counteracts cyclopamine inhibition of Smo. SAG induces firefly luciferase expression in Shh-LIGHT2 cells with an EC₅₀ of 3 nM and then inhibits expression at higher concentrations. In Smo-expressing Cos-1 cells, SAG yields an apparent dissociation constant (K_D) of 59 nM for the SAG/Smo complex. SAG and purmorphamine verride the inhibitory effect of robotnikinin since Smo functions downstream of Shh/Ptc1.

In Vivo: In CD-1 mice, SAG (1.0 mM) or NELL-1 (600 μg/ml) alone results in increased bone formation at 4 and 8 weeks, but significantly greater bone formation with both components combined (SAG + NELL-1). The combination of the two compounds exhibits a significant increase in new bone formation, accompanied by increased defect vascularization. SAG (15, 17, or 20 mg/kg, i.p.) induces pre-axial polydactyly prevalently. The highest SAG dose is effective in ca. 80% of the embryos and increased Gli1 and Gli2 mRNA expression in the limb bud, with Gli1 mRNA being the most upregulated.

相关产品：Reprogramming Compound Library  |  Anti-Aging Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Bioactive Compound Library Plus  |  Wnt/Hedgehog/Notch Compound Library  |  Cyclopamine  |  SAG  |  Purmorphamine  |  Erismodegib  |  Glasdegib  |  SANT-1  |  20(S)-Hydroxycholesterol  |  Halcinonide  |  MK-4101  |  Taladegib  |  Saridegib  |  Jervine  |  LEQ506  |  ALLO-2  |  BMS-833923  |  MRT-83  |  PF-5274857  |  CUR61414

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