MCE 的所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。

AlbA-DCA

CAS No. :

MCE 站：AlbA-DCA

产品活性：AlbA-DCA 是一种缀合物，是通过 Albiziabioside A (AlbA) 连接至二氯乙酸 (DCA) 亚基形成的。AlbA-DCA 可以诱导细胞内 ROS 显着增加，并减轻乳酸在肿瘤微环境中的积累，还可以选择性杀死癌细胞并诱导凋亡。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Reactive Oxygen Species  |  Apoptosis

In Vitro: AlbA-DCA exhibits the cytotoxicity against the MCF-7 cells, HCT116 cells, A375 cells, 4T1 cells, HBMEC cells and LO2 cells with IC₅₀ values of 0.43 μM, 3.87 μM, 3.78 μM, 1.31 μM, 38.20 μM and 53.14 μM, respectively.
AlbA-DCA (2 μM; 24 hours; MCF-7 cells) treatment induces apoptotic cell death in MCF-7 cells.
AlbA-DCA (2 μM; MCF-7 cells) treatment could significantly up-regulate the expression of cytochrome c and down-regulate the expression of antiapoptotic protein Bcl-2. AlbA-DCA significantly enhances the expression of caspase-9.

In Vivo: AlbA-DCA (2 mg/kg; subcutaneous injection; every 2 days; for 2 weeks; nude mice) treatment displays antitumor efficacy and almost completely suppresses tumor progression, and no mouse deaths and no significant changes in body weight are observed. AlbA-DCA has no obvious toxicity of liver and kidney and no major abnormality is observed in heart, liver, spleen, lung, and kidney.

相关产品：MG-132  |  LY294002  |  Actinomycin D  |  Mitomycin C  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Paclitaxel  |  Y-27632 dihydrochloride  |  SP600125  |  Sorafenib  |  Angiotensin II human  |  MK-2206 dihydrochloride  |  H2DCFDA  |  5-Fluorouracil  |  Trametinib  |  Tamoxifen  |  Bortezomib  |  Gemcitabine  |  Pexidartinib  |  Acetylcysteine  |  Decitabine  |  BAY 11-7082  |  2-Deoxy-D-glucose  |  Docetaxel  |  Verteporfin  |  Temozolomide  |  Dasatinib  |  Ruxolitinib  |  Etoposide

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。