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Remogliflozin etabonate

CAS No. : 442201-24-3

MCE 站：Remogliflozin etabonate

产品活性：Remogliflozin etabonate (GSK189075) 是一种具有口服活性的，选择性和低亲和力的钠葡萄糖共转运蛋白 (SGLT2) 抑制剂，对 hSGLT2，rSGLT2，hSGLT1，rSGLT1 的 K_i 值分别为 1.95 μM，43.1 μM，2.14 μM，8.57 μM。Remogliflozin etabonate 是一种基于苄基吡唑葡糖苷的前药，在体内被代谢成其活性形式，瑞格列净 (Remogliflozin)。Remogliflozin etabonate 在啮齿动物模型中显示出抗糖尿病功效。

研究领域：Membrane Transporter/Ion Channel

作用靶点：SGLT

In Vivo: Remogliflozin etabonate (GSK189075; 10 or 30 mg/kg; orally; twice daily for 6 weeks) significantly reduced both the FPG and GHb levels in a dosedependent manner.
Remogliflozin etabonate (3, 10, 30 mg/kg; orally) increases urinary glucose excretion in a dose-dependent manner. Remogliflozin etabonate dose-dependently inhibits the increase in plasma glucose after glucose loading and decreases the plasma insulin in normal rats.
Remogliflozin etabonate (1-10 mg/kg; orally) decreases the blood glucose and reduces the AUC_{0–6 h} for blood glucose in a dose-dependent manner.
Remogliflozin etabonate (high-fat diet containing 0.01, 0.03, or 0.1% remogliflozin etabonate for 8 weeks) reduces the levels of plasma glucose, plasma insulin, and GHb in a dose-dependent manner, and it suppresses the development of hypertriglyceridemia in male GK rats (6 weeks of age).

相关产品：Orally Active Compound Library  |  Bioactive Compound Library Plus  |  Membrane Transporter/Ion Channel Compound Library  |  Diabetes Related Compound Library  |  Dapagliflozin  |  Empagliflozin  |  Canagliflozin  |  Phlorizin  |  Phloretin  |  Sotagliflozin  |  Ertugliflozin  |  Ipragliflozin  |  Tofogliflozin (hydrate)  |  Licogliflozin  |  Bexagliflozin  |  Trilobatin  |  KGA-2727  |  LX2761  |  Mizagliflozin  |  SGL5213  |  SGLT inhibitor-1  |  HSK0935  |  Velagliflozin

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