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Inz-1

CAS No. : 897776-15-7

MCE 站：Inz-1

产品活性：Inz-1 是一种有效的、选择性的酵母线粒体细胞色素 bc1 (mitochondrial cytochrome bc1) 抑制剂 (IC₅₀=8.092 μM)，优于对人的 (IC₅₀=45.320 μM)。Inz-1 逆转白色念珠菌对氟康唑 (HY-B0101) 或其他三唑抗真菌试剂的耐药性。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：Cytochrome P450  |  Fungal

In Vitro: Inz-1 (0-16 μM; 24 hours) inhibits the growth of the model yeast?S. cerevisiae?(strain BY4741) and?C. albicans?(SC5314) in media containing glucose or glycerol as the sole carbon source, while only mildly slowing growth in glucose.?
Inz-1 (0-100 μM; 24 hours) shows inhibition of yeast cytochrome B enzymatic activity in a concentration -dependent manner in both wild-type and F90Y mutant mitochondria. It exhibits inhibition of cytochrome bc1 from both?S. cerevisiae and?C. albicans?with IC₅₀ value of 2.5 μM and 8.0 μM, respectively.
Inz-1 (0-100 μM; 24 hours) is selective for yeast over human cytochrome bc1, it inhibits human cytochrome bc1 activity only weakly, with an IC₅₀?of 45.3 μM, 5.6-fold higher than the IC₅₀?for the?C. albicans?homolog in mitochondria purified from HEK293 human embryonic kidney cells.
Inz-1 (0-100 μM; 24 hours) inhibits proliferation under forced respiration conditions only at 32 μM，and only mildly at that concentration.
Inz-1 is against candida, human enzyme with IC₅₀ values of 8.092 μM and 45.320 μM, respectively. It against Candida and HepG2 respiring growth with IC₅₀ values of 1.655 uM and >32 μM, respectively.

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