MCE 的所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。

Factor D inhibitor 6

CAS No. : 1386455-51-1

MCE 站：Factor D inhibitor 6

产品活性：Factor D inhibitor 6 是一种有效的，高选择性，具有口服活性的因子 D (factor D) 抑制剂，IC₅₀ 为 30 nM，K_d 为 6 nM。Factor D inhibitor 6 对因子 B，激肽和凝集素补体途径激活以及广泛的受体，离子通道，激酶和蛋白酶等无活性。

研究领域：Immunology/Inflammation

作用靶点：Complement System

In Vitro: Factor D inhibitor 6 (compound 6) effectively blocks both alternative pathway (AP)-mediated hemolysis in 10% human serum (IC₅₀ = 6 nM) and AP-induced membrane-attack complex (MAC) formation in lepirudinanticoagulated 50% human whole blood (IC₅₀ = 0.14 μM).
Factor D inhibitor 6 (compound 6) shows modest inhibition of murine FD (IC₅₀ = 0.86 μM).
Factor D inhibitor 6 (compound 6) inhibits both hemolysis and component 3 (C3) deposition on the surface of red blood cells (RBCs) with an IC₅₀ value of 70 nM, consistent with inhibition of the AP amplification loop.

In Vivo: Factor D inhibitor 6 (Compound 6; 1-10 mg/kg; Oral gavage; once; C57Bl/6 mice) treatment dosed-ependently inhibits complement activation, with full inhibition at 10 mg/kg. Factor D inhibitor 6 shows sustained inhibition of LPS-induced AP activation for at least 8 h post-dose with an EC₅₀ of 0.034 μM.

相关产品：Dexamethasone  |  Cyclosporin A  |  SB290157 trifluoroacetate  |  Avacopan  |  PMX 205 Trifluoroacetate  |  Compstatin  |  Danicopan  |  Leukadherin-1  |  W-54011  |  BCX 1470 methanesulfonate  |  C3a (70-77) TFA  |  LNP023 hydrochloride  |  AMY-101 TFA  |  PMX-53  |  Complement C5-IN-1  |  Compstatin control peptide  |  FD-IN-1  |  TLQP-21

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。