MCE 的所有产品仅用作科学研究，我们不为任何个人用途提供产品和服务。

Piericidin A

CAS No. : 2738-64-9

MCE 站：Piericidin A

产品活性：Piericidin A (AR-054) 是一种天然线粒体 NADH-泛醌氧化还原酶 (复合物 I; complex I) 抑制剂。Piericidin A 是一种有效的神经毒素，通过其对 NADH-泛醌还原酶 (NADH-ubiquinone reductase) 的作用破坏电子传输系统，从而抑制线粒体呼吸。Piericidin A 还是一种潜在的群体感应抑制剂，可抑制胡萝卜欧文氏菌亚种 atroseptica (Eca) 的毒力基因的表达。Piericidin A 是一种 ADC 细胞毒素，具有抗菌，抗癌，杀虫活性。

研究领域：Anti-infection  |  Antibody-drug Conjugate/ADC Related

作用靶点：Bacterial  |  ADC Cytotoxin  |  Antibiotic

In Vitro: In a cell free assay, the potency of Piericidin A to inhibit mitochondrial complex I is ?2 fold smaller than the one of annonacin. In cultured neurons, Piericidin A potently induces the redistribution of phosphorylated tau from the dendrites into the cell soma and induces cell death.
The viability of Tn5B1-4 cells is inhibited by Piericidin A in a time- and concentration-dependent manner with IC₅₀ value of 0.061 μM, whilst Piericidin A shows slight inhibitory effect on the viability of HepG2 and Hek293 cells with IC₅₀ value of 233.97 μM and 228.96 μM, respectively. Piericidin A induces apoptosis of Tn5B1-4 cells coincides with a decrease in the mitochondrial membrane potential.

In Vivo: Piericidin A (0.5 mg/kg/d; for 28 days via osmotic minipumps) significantly increases the number of phospho-tau immunoreactive cells in the cerebral cortex in P301S^+/+ mice. Piericidin A leads to increased levels of pathologically phosphorylated tau only in P301S^+/+ mice. The synaptic density is reduced by Piericidin A treatment in P301S^+/+ mice. Exposure to Piericidin A aggravates the course of genetically determined tau pathology.

相关产品：Rapamycin  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Paclitaxel  |  Chloroquine phosphate  |  Puromycin dihydrochloride  |  Staurosporine  |  Dexamethasone  |  Etoposide  |  Tunicamycin  |  5-Azacytidine  |  Doxycycline (hyclate)  |  Brefeldin A  |  G-418 disulfate  |  CCCP  |  Nigericin sodium salt  |  Bleomycin sulfate  |  Resveratrol  |  Tacrolimus  |  Hygromycin B  |  Tanespimycin  |  α-Amanitin  |  Streptozocin  |  Oligomycin A  |  Vancomycin hydrochloride  |  Ionomycin  |  Amphotericin B  |  Anisomycin  |  Monomethyl auristatin E  |  Methotrexate

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。