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Sphingosine-1-phosphate

CAS No. : 26993-30-6

MCE 站：Sphingosine-1-phosphate

产品活性：Sphingosine-1-phosphate (S1P) 是 S1P_1-5 受体 (S1P_1-5 receptors) 的激动剂和 GPR3、GPR6、GPR12 的配体。Sphingosine-1-phosphate 是细胞内的第二信使，动员 Ca²⁺ 作为 G 蛋白偶联受体的细胞外配体。Sphingosine-1-phosphate 是由鞘磷脂 (HY-113498) 或其他膜磷脂生成的重要脂质介质。

研究领域：Metabolic Enzyme/Protease  |  GPCR/G Protein

作用靶点：Endogenous Metabolite  |  LPL Receptor

In Vitro: S1P (1 μM) induces a significant Ca²⁺ releases in HEK293 cells under serum starvation conditions (1% FCS).
In a functional Ca²⁺ assay, Suramin (HY-B0879) alone does not exert any effect on intracellular Ca²⁺ release via gpr3, gpr6 or gpr12. In contrast, S1P (1 μM) induces Ca²⁺ release of gpr3, gpr6 and gpr12 in the presence of Suramin (HY-B0879) various concentrations in transfected HEK293 cells.
In a functional Ca²⁺ assay,S1P (3-3000 nM) in the presence Suramin (300 μM), exhibits nanomolar EC₅₀ values for gpr3 (EC₅₀=29 nM), gpr6 (EC₅₀=15 nM) and gpr12 (EC₅₀=24 nM), rat gpr3 (EC₅₀=68 nM),respectively in HEK293 cells.
S1P increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1?and G_qi5, which allows for phospholipase C stimulation by G_i?proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2?and S1P3?receptors (EC₅₀s = 8 and 11 nM, respectively).

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