型号:
产品价格:电议      采购度:1610      原产地:美洲
发布时间:2021/6/2 11:08:21 所属地区:国外 国外
简要描述:
Cibinetide (ARA290) 是一种 EPO 衍生物,为特异性的 erythropoietin/CD131 heteroreceptor 的激动剂,常用于神经系统疾病研究。
标签:ARA290
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CAS No. : 1208243-50-8
MCE 站:Cibinetide
产品活性:Cibinetide (ARA290) 是一种 EPO 衍生物,为特异性的 erythropoietin/CD131 heteroreceptor 的激动剂,常用于神经系统疾病研究。
研究领域:Others
作用靶点:Others
In Vitro: Cibinetide (ARA290) enhances the proliferation, migration, and resistance to H2O2-induced apoptosis of endothelial colony-forming cells (ECFCs). Cibinetide (ARA290) is an EPO-analog peptide without hematopoietic side-effects but may have neurotrophic and antidepressant effects.
In Vivo: After ECFC transplantation to mice with CLI, a single Cibinetide (ARA290) injection enhances the ischemic/non-ischemic ratio of hindlimb blood flow and capillary density after 28 days and the homing of radiolabeled transplanted cells to the ischemic leg 4 h after transplantation. Cibinetide (ARA290; 30 μg/kg, s.c.) prevents progressive worsening of glucose control without affecting body weight of rats. Cibinetide significantly decreases glucose AUCs in IPGTT in GK rats. Low-dosage Cibinetide (35 μg/kg, i.p.) treatment only slightly attenuates the EAE severity in rats. Cibinetide-treating group (70 μg/kg, i.p.) significantly delays the onset, decreases the neurologic severity and shortens the duration of EAE in a dose-dependent way.
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更新时间:2024/1/2 10:11:58
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