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ReACp53

CAS No. :

MCE 站：ReACp53

产品活性：ReACp53 能够抑制 p53 amyloid 的形成, 挽救 p53 在癌细胞中的作用。

研究领域：Apoptosis

作用靶点：MDM-2/p53

In Vitro: ReACp53 penetrates into HGSOC primary cancer cells ａnd converts mutant p53 from a punctate state into soluble WT-like p53. ReACp53 also induces cancer cell death, cell cycle arrest ａnd results in p53 degradation. ReACp53 specifically affects cell viability ａnd proliferation of cancer cells bearing mutant p53 but not wild type when grown as organoids.

In Vivo: Only mutant p53-bearing tumors in the ReACp53-treated mice cohorts are 80-90% smaller in weight than the control cohort, confirming the ability of ReACp53 to limit tumor proliferation ａnd shrink tumors. A significant reduction of Ki67 positive cells is evident in ReACp53-treated OVCAR3 xenografts, indicative of a reduced proliferative index. Similar results are observed in the minimal residual disease model. In the paradigm, administration of ReACp53 results in a significant increase in p21 ａnd MDM2 transcription in OVCAR3 but not MCF7 xenografts. A significantly increased population is also found in G0/G1 phase, supporting proliferative arrest upon ReACp53 administration in vivo.

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