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VIP(6-28)(human, rat, porcine, bovine)

CAS No. : 69698-54-0

MCE 站：VIP(6-28)(human, rat, porcine, bovine)

产品活性：VIP(6-28)(human, rat, porcine, bovine) 是一种外源性血管活性肠肽 (VIP) 拮抗剂。

研究领域：Others

作用靶点：Others

In Vitro: VIP(6-28) is an effective VIP antagonist in the superior cervical ganglion (SCG) , ａnd results obtained using this analog indicate that endogenous VIP can participate in a positive feedback loop in injured sympathetic neurons in which it enhances its own expression. VIP(6-28), when added to short-term cultures of adult SCG at a concentration of 10, 30, or 100 μM, reduces the increase in cAMP levels produced by stimulation with 10 μM VIP by 52, 64, or 81%, respectively. At any of these concentrations tested, VIP(6-28) by itself does not alter cAMP levels. In contrast to its ability to reduce the VIP-stimulated elevation in cAMP levels by 64%, the addition of 30 μM VIP(6-28) to culture medium does not significantly alter cAMP levels measured after stimulation of adult ganglia with either isoproterenol or forskolin (10 μM each). Similar results on the ability of VIP(6-28) to block VIP-stimulated increases in cAMP levels are obtained in neuron-enriched ａnd in non-neuronal cell-enriched dissociated cultures.

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