型号：
产品价格：电议 采购度：1646 原产地：美洲
发布时间：2021/6/2 12:09:10 所属地区：国外 国外
简要描述：
DTP3 TFA 是一种选择性的 GADD45β/MKK7 (生长停滞和 DNA 损伤诱导 β/促分裂原活化的蛋白激酶激酶 7) 抑制剂。DTP3 TFA 靶向 NF-κB 途径下游的一种重要的癌症选择性细胞存活模块。
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CAS No. :
MCE 站：DTP3 TFA
产品活性：DTP3 TFA 是一种选择性的 GADD45β/MKK7 (生长停滞和 DNA 损伤诱导 β/促分裂原活化的蛋白激酶激酶 7) 抑制剂。DTP3 TFA 靶向 NF-κB 途径下游的一种重要的癌症选择性细胞存活模块。
研究领域：Cell Cycle/DNA Damage | MAPK/ERK Pathway
作用靶点：DNA/RNA Synthesis | JNK
In Vitro: DTP3 (10 μM; 1-21 days) causes the potent ａnd tumor-selective induction of JNK activation ａnd apoptosis, as shown by the appearance of phosphorylated JNK, as early as 24 hours.
In Vivo: DTP3 TFA (s.c.; 14.5 mg/kg/day; 28 days) has shown a dramatic shrinkage of the tumors, ａnd virtually eradicates established subcutaneous myeloma xenografts in mice.
DTP3 TFA (intravenous injection; 10 mg/kg/day) has t1/2 of 1.26 hours, CL of 27.13 ML/min/kg, ａnd Vd of 2.80 L/kg.
相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | NF-κB Signaling Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Anti-Blood Cancer Compound Library | SP600125 | Oxaliplatin | Gemcitabine | Bleomycin sulfate | Carboplatin | Cytarabine | Favipiravir | Methotrexate | Streptozocin | Anisomycin | Thymidine | Fludarabine | Epirubicin hydrochloride | Daunorubicin hydrochloride | Capecitabine | Hydroxyurea | Plicamycin | Astragaloside IV | Urolithin A | ML216 | Folic acid | Brequinar | Halofugi | Tomatidine | Guggulsterone | Triciribine | Floxuridine | Galidesivir hydrochloride
更新时间：2024/1/2 10:11:58
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