MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

GLP-1(7-36), amide TFA

CAS No. :

MCE 站：GLP-1(7-36), amide TFA

产品活性：GLP-1(7-36), amide TFA 是一种主要的肠道激素，在葡萄糖的刺激下，它能促使胰岛 β 细胞分泌胰岛素。

研究领域：GPCR/G Protein

作用靶点：Glucagon Receptor

In Vitro: Cells treated with phorbol 12-myristate 13-acetate for 2 h has significantly higher active GLP-1(7-36) Acetate (Human GLP-1-(7-36)-amide Acetate) concentrations in the media than those in the control. The glucose treatment also increases active GLP-1 secretion from cells in dose-dependent manner. Palmitic, oleic, linoleic or linolenic acid dose-dependently stimulated active GLP-1 secretion from cells. Active GLP-1 secretion is significantly greater with unsaturated fatty acids such as oleic, linoleic ａnd linolenic acids than with palmitic acid. The treatment of NCI-H716 cells with CPE dose-dependently increases active GLP-1 concentrations in the media. A 37% increase is observed in active GLP-1 secretion from these cells at a concentration of 0.1 % CPE.

In Vivo: Gastric administration of glucose increases active GLP-1(7-36) amide levels in the portal blood after 10 min, followed by a marked decrease at 30 min. The gastric administration of TO also increases active GLP-1 levels after 10 min, ａnd followed by a decrease to basal levels at 60 min. Individually, glucose ａnd TO increase the secretion of GLP-1 in a dose-dependent manner. Furthermore, the co-administration of glucose ａnd TO additively increase peak GLP-1 levels. CPE-administered mice have higher active GLP-1 levels in the portal blood at 10 ａnd 30 min than those in the control mice. When glucose is administered with CPE, active GLP-1 ａnd insulin levels in the portal blood are slightly higher in CPE-administered mice than in the control mice. High-fat diet-fed C57BL/6J mice develop hyperglycaemia ａnd impair glucose tolerance.

相关产品：Bioactive Compound Library Plus  |  Exendin-4  |  Liraglutide  |  Glucagon (1-29), bovine, human, porcine  |  Avexitide  |  Adomeglivant  |  GLP-1(7-37)  |  GLP-1(7-36), amide acetate  |  BETP  |  GLP-2(1-33)(human)  |  GRA Ex-25  |  Cotadutide acetate  |  Glucagon-like peptide 1 (1-37), human TFA  |  NNC-0640  |  Taspoglutide  |  GLP-1 moiety from Dulaglutide  |  Glucagon receptor antagonists-2  |  Exendin-3/4 (59-86)  |  FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS  |  GLP-1(28-36)amide  |  GLP-1(32-36)amide  |  GLP-1(9-36)amide  |  Glucagon receptor antagonists-1  |  GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS  |  HAEGTFT  |  HAEGTFTSD  |  HAEGTFTSDVS

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。