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Melittin TFA

CAS No. :

MCE 站：Melittin TFA

产品活性：Melittin TFA 是一种PLA₂激活剂，可刺激低分子量 PLA₂ 的活性，而不会提高高分子量 PLA₂ 的活性。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phospholipase

In Vitro: Melittin, an immunologically related PLA₂ stimulating peptide from bee venom, increases the activity of the high molecular weight enzyme. Melittin is a cytotoxic peptide from bee venom. Melittin exhibits toxicity against both A2780CR ａnd A2780 cells, with IC₅₀ values of 4.5 ａnd 6.8 μg/mL, respectively. Melittin has natural anti-bacterial, anti-viral, ａnd anti-inflammatory properties. It has also been shown to have diverse anticancer effects in several different cancer cell lines including those of gastric, breast, ovarian, liver, prostate, cervical, ａnd lung origins. The mechanisms by which Melittin, an amphipathic haemolytic peptide, exerts its potential anticancer effects include inhibition of cell proliferation, induction of apoptosis, ａnd direct necrosis. Melittin can also prevent EGF-induced cell invasion through its inhibition of the PI3K/Akt/mTOR signaling pathway, but this is primarily related to breast cancer cells.

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