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Disitertide TFA

CAS No. :

MCE 站：Disitertide TFA

产品活性：Disitertide (P144) TFA 是转化生长因子 TGFβ1 的多肽抑制剂，特异性的阻断其与受体间的相互作用。Disitertide (P144) TFA 也是PI3K 的抑制剂和凋亡 (apoptosis) 诱导剂。

研究领域：Stem Cell/Wnt  |  TGF-beta/Smad  |  PI3K/Akt/mTOR  |  Apoptosis

作用靶点：TGF-beta/Smad  |  PI3K  |  Apoptosis

In Vitro: Disitertide (100 μg/mL) suppresses the protein expression levels of PI3K ａnd p-Akt, ａnd induce the protein expression of Bax in MC3T3-E1 cells.
Disitertide (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness ａnd chemoresistance.
Disitertide (P144, 10 μg/mL to 200 μg/mL) affects proliferation, induces apoptosis as well as anoikis in A172 ａnd U-87 MG GBM cell lines.

In Vivo: Disitertide (Topical application, 300 μg/mL) may promote scar maturation ａnd clinical improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment.

相关产品：Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Stem Cell Signaling Compound Library  |  TGF-beta/Smad Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Differentiation Inducing Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  MG-132  |  3-Methyladenine  |  LY294002  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Paclitaxel  |  Y-27632 dihydrochloride  |  Angiotensin II human  |  Acetylcysteine  |  SP600125  |  5-Fluorouracil  |  Staurosporine  |  Bortezomib  |  Tamoxifen  |  2-Deoxy-D-glucose  |  Gemcitabine  |  Verteporfin  |  Decitabine  |  Temozolomide  |  BAY 11-7082  |  Etoposide  |  DAPT  |  CCCP  |  Rote  |  Stattic  |  Etomoxir  |  Docetaxel  |  Wortmannin  |  Fulvestrant

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