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LyP-1

CAS No. : 454487-07-1

MCE 站：LyP-1

产品活性：LyP-1 是一种环状 9 个氨基酸的肿瘤的定位肽，在多种肿瘤相关细胞中，选择性结合其 p32 receptor 蛋白。

研究领域：Others

作用靶点：Others

In Vivo: LyP-1 (8 weeks) shows a remarkable reduction in plaque formation ａnd plaque occupation rates in the LyP-1-treated group. In addition, a higher apoptotic rate in macrophages released from hypoxic plaques is observed after the treatment of LyP-1when compared to control peptide.
The LyP-1 peptide is labeled with a near-infrared fluorophore (Cy5.5) for optical imaging.
At days 3, 7, 14 ａnd 21 after inoculation with 4T1 cells, tumor-bearing BALB/C mice is injected Cy5.5-LyP-1 (0.8 nmol) through the middle phalanges of the upper extremities of the tumor-bearing mice. The fluorescence intensities were 0.024, 0.038, 0.048 ａnd 0.106×10⁶ photon/cm²/sec respectively at days 3, 7, 14 ａnd 21 after tumor cell inoculation, which are 1.02, 1.63, 2.04, ａnd 4.52-fold higher than in the contralateral LNs. Cy5.5-LyP-1 staining in LNs co-localized with LYVE-1, suggesting lymphatics-specific binding of LyP-1 peptide.

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