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SC79

CAS No. : 305834-79-1

MCE 站：SC79

产品活性：SC79，一个特异的、能透过血脑屏障的 Akt 激动剂，可激活胞质中 Akt，并抑制 Akt 膜转位。SC79 特异性结合Akt 的PH 结构域。

研究领域：PI3K/Akt/mTOR

作用靶点：Akt

In Vitro: SC79 augmentes Akt phosphorylation at both the Thr308 ａnd S473 sites.
SC79 (10.96 μM) induces cytosolic phosphorylation of Akt. SC79 enhances IGF1-induced Akt phosphorylation in both serum-starved cells ａnd cells grown in serum-rich medium.
SC79 reduces neuronal excitotoxicity ａnd prevents stroke-induced neuronal death. SC79 suppresses PHAKTM-GFP plasma membrane translocation.
SC79 restores proliferation of BRAT1 knockdown cells, ａnd reduces the production of superoxide in mitochondria of MitoSox positive cells.
SC79 upregulates FLIPL/S expression ａnd consequently suppresses caspase-8 activation.

In Vivo: SC79 treatment, even at much high dose (0.4 mg/g of body weight), does not induce any detectable changes in body weight, survival rate, appearance, ａnd behavior in mice.
SC79 (10 mg/kg, i.p.) Protects C57BL/6 mice from fas-induced fulminant hepatic failure.
SC79 protects hepatocytes from TNFα-mediated apoptosis ａnd mice from Gal/LPS-induced liver injury ａnd damage.

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