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IQZ23

CAS No. : 2415643-79-5

MCE 站：IQZ23

产品活性：IQZ23 通过激活 AMPK 信号通路抑制脂肪细胞分化。IQZ23 降低 3T3-L1 脂肪细胞中的甘油三酸酯水平 (EC₅₀=0.033 μM)。IQZ23 可用于肥胖症和相关代谢紊乱的研究。

研究领域：Epigenetics  |  PI3K/Akt/mTOR

作用靶点：AMPK

In Vitro: IQZ23 activates AMPK pathway by modulating ATP synthase activity.
IQZ23 (0.3 ａnd 1.0 μM) markedly decreases the protein level of adipogenic factors C/EBPα, PPARγ, ａnd sterol regulatory element-binding protein 1c (SREBP-1c)) after 24 h treatment as well as the level of fatty acid synthesis related proteins fatty acid synthase (FAS), acetyl CoA carboxylase (ACC), stearoyl-CoA desaturase 1 (SCD1) after 6 days of treatment in 3T3-L1 adipocytes.

In Vivo: IQZ23 (20 mg/kg, i.p.) treatment significantly reverses high fat ａnd cholesterol diet (HFC)- induced body weight increases ａnd accompanying clinical symptoms of obesity in mice but without indicative toxicity.
IQZ23 exhibits moderate terminal elimination half-lives (rat 4.2±0.3 h) ａnd Cmax (rat 37.1±7.0 ng/mL) following oral administration (rat 5 mg/kg).
IQZ23 exhibits terminal elimination half-lives (rat 4.4±0.4 h) following intravenous administration (rat 2 mg/kg).

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