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AC710

CAS No. : 1351522-04-7

MCE 站：AC710

产品活性：AC710是有效的 PDGFR 抑制剂，对FLT3，CSF1R，KIT，PDGFRα 和 PDGFRβ的K_d 值分别为0.6，1.57，1，1.3，1.0。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：PDGFR  |  c-Kit  |  FLT3

In Vivo: At 0.3 mg/kg of AC710, tumor growth is temporally inhibited, ａnd growth resumes quickly thereafter. At 3 ａnd 30 mg/kg of AC710, tumors regress completely, ａnd the tumor volume stays suppressed for an extended period after dosing is halted. No body weight loss is observed in animals treated with AC710 at all doses, indicating that it is well tolerated in mice at efficacious doses. AC710 exhibits a significant impact on disease in a dose-dependent fashion in a mouse collagen-induced arthritis (CIA) model, at a dose as low as 3 mg/ kg for 15 days (day 0-14). At 10 ａnd 30 mg/kg, AC710 demonstrates equivalent or slightly better efficacy in reducing the joint swelling ａnd inflammation than dexomethasone administered at a safe dose. AC710 is well tolerated at the tested doses.

相关产品：Covalent Screening Library Plus  |  Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  Anti-Cancer Compound Library  |  Covalent Screening Library  |  Reprogramming Compound Library  |  Anti-Blood Cancer Compound Library  |  Sunitinib  |  Imatinib  |  SU 5402  |  Cediranib  |  AT9283  |  Gandotinib  |  KW-2449  |  Lestaurtinib  |  CG-806  |  AST 487  |  Ki20227  |  Motesanib  |  SU14813  |  PP121  |  Sennoside B  |  PP58  |  ISCK03  |  AG 1295  |  JNJ-47117096 hydrochloride  |  Methylnissolin  |  PLX647  |  BPR1J-097 Hydrochloride  |  Crotonoside  |  SU16f  |  Trapidil  |  Tyrosine kinase-IN-1  |  SKLB4771

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