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Glycolysis Compound Library

MCE 站：Glycolysis Compound Library

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.MCE provides a unique collection of 421 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Description & Advantages:

?   A unique collection of 421 glycolysis-related small molecules for high throughput screening (HTS) and high content screening (HCS).

?   Targets such as hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc.

?   A useful tool for glucose metabolism research and anti-cancer drug discovery.

?   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

?   Structurally diverse, medicinally active, and cell permeable.

?   More detailed compound information with structure, IC₅₀, and brief introduction.

?   NMR and HPLC validated to ensure high purity and quality.

?   All compounds are in stock and continuously updated.

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