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NF-κB Signaling Compound Library

MCE 站：NF-κB Signaling Compound Library

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.MCE owns a unique collection of 452 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

Description & Advantages:

?   A unique collection of 452 NF-κB signaling related small molecule compounds for high throughput screening (HTS) and high content screening (HCS).

?   Targets such as IKK, Keap1-Nrf2, NF-κB, etc.

?   A powerful tool for researching the mechanism behind cancer, drug screening based on NF-κB signaling pathway and other pharmaceutical and biological applications.

?   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

?   Structurally diverse, medicinally active, and cell permeable.

?   More detailed compound information with structure, IC₅₀, and brief introduction.

?   NMR and HPLC validated to ensure high purity and quality.

?   All compounds are in stock and continuously updated.

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