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Wnt/Hedgehog/Notch Compound Library

MCE 站：Wnt/Hedgehog/Notch Compound Library

The developmental proteins Hedgehog, Notch and Wnt are key regulators of cell fate, proliferation, migration and differentiation in several tissues. Their related signaling pathways are frequently activated in tumors, and particularly in the rare subpopulation of cancer stem cells. The Wnt signaling pathway is a conserved pathway in animals. Deregulated Wnt signaling has catastrophic consequences for the developing embryo and it is now well appreciated that defective Wnt signaling is a causative factor for a number of pleiotropic human pathologies, including cancer. Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. It plays an important role in cell-cell communication, and further regulates embryonic development.MCE designs a unique collection of 198 Wnt/Hedgehog/Notch signaling pathway-related small molecules. Wnt/Hedgehog/Notch Compound Library serves as a useful tool for stem cell research and anti-cancer drug screening.

Description & Advantages:

?   A unique collection of 198 small molecule inhibitors with biological activity used for Wnt/Hedgehog/Notch pathway research and screening.

?   Targets include Notch, Gli, GSK-3, Hedgehog, Porcupine, sFRP-1, Smo, Wnt, β-catenin, etc.

?   A useful tool for the research of Wnt/Hedgehog/Notch-related regulation and diseases.

?   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

?   Structurally diverse, medicinally active, and cell permeable.

?   More detailed compound information with structure, IC₅₀, and brief introduction.

?   NMR and HPLC validated to ensure high purity and quality.

?   All compounds are in stock and continuously updated.

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