型号:
产品价格:电议      采购度:1616      原产地:美洲
发布时间:2021/7/16 8:45:38 所属地区:上海 上海市
简要描述:
Cholic acid 是肝脏中产生的主要胆汁酸,通常与甘氨酸或牛磺酸缀合,有助于脂肪吸收和胆固醇排泄。
标签:cholic
产品详情
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 81-25-4
MCE 站:Cholic acid
产品活性:Cholic acid 是肝脏中产生的主要胆汁酸,通常与甘氨酸或牛磺酸缀合,有助于脂肪吸收和胆固醇排泄。
研究领域:Metabolic Enzyme/Protease
In Vitro: Cholic acid competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway.
In Vivo: Cholic acid feeding leads to increased CYP2D6 expression in CYP2D6-humanized mice. As a cholestasis model, Tg-CYP2D6 mice are fed a Cholic acid (CA)-supplemented diet for over 1 week. The treatment is known to increase bile acid pool size by 2-fold and to replace ~90% of bile acids with CA, recapitulating the features of cholestatic conditions in humans.
相关产品:Natural Product Library Plus | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Natural Product Library | FDA-Approved Drug Library | Human Endogenous Metabolite Compound Library | Drug Repurposing Compound Library | Orally Active Compound Library | Traditional Chinese Medicine Monomer Library | FDA Approved & Pharmacopeial Drug Library | Rapamycin | 3-Methyladenine | Acetylcysteine | 5-Fluorouracil | ATP | Retinoic acid | Hydrocortisone | Docetaxel | Estradiol | Melatonin | Nicotinamide | Cytarabine | Isoprenaline hydrochloride | Prostaglandin E2 | Acetaminophen | (-)-Epigallocatechin Gallate | β-Nicotinamide mononucleotide | Calcitriol | DHEA | Liothyronine | NAD+ | Luteolin | Thymidine | Docosahexaenoic Acid | Kaempferol | Palmitic acid | Cyclopamine | Genistein | L-Glutathione reduced | Progesterone
品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物;
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
• 专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。
更新时间:2024/1/2 10:12:49
留言咨询
温馨提示
1.遵守中华人民共和国有关法律、法规,尊重网上道德,承担一切因您的行为而直接或间接引起的法律责任。
2.请您真实的反映产品的情况,不要捏造、诬蔑、造谣。如对产品有任何疑问,也可以留言咨询。
3.未经本站同意,任何人不得利用本留言簿发布个人或团体的具有广告性质的信息或类似言论。
相关新闻
相关产品