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Geldanamycin

CAS No. : 30562-34-6

MCE 站：Geldanamycin

产品活性：Geldanamycin是 Hsp90 抑制剂，具有抗许多革兰氏阳性和一些革兰氏阴性细菌的活性。Geldanamycin 还具有抗流感病毒 H5N1 的活性。

研究领域：Cell Cycle/DNA Damage  |  Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：HSP  |  Bacterial  |  Influenza Virus  |  Antibiotic

In Vitro: Geldanamycin significantly delays and reduces viperin expression, indicating that IRF3 is involved in viperin induction in RAW264.7 cells. Geldanamycin (GA), a benzoquinone ansamycin, protected against neuronal injury induced by oxygen-glucose deprivation (OGD)/zVAD treatment in cultured primary neurons. More importantly, Geldanamycin decreases RIP1 protein level in a time and concentration-dependent manner. Geldanamycin also decreases the Hsp90 protein level, which causes instability of RIP1 protein, resulting in decreased RIP1 protein level but not RIP1 mRNA level after Geldanamycin treatment. Geldanamycin (GA) is identified as the first natural product inhibitor of Hsp90 that binds to the N-terminal ATPase domain of Hsp90 to inhibit its chaperone function, and significantly induces tumor cell death via an apoptotic mechanism.

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