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产品价格:电议      采购度:1593      原产地:美洲
发布时间:2021/7/16 9:02:10 所属地区:上海 上海市
简要描述:
Camptothecin (Campathecin) 是有效的 DNA拓扑异构酶 I 抑制剂,IC50 值为 679 nM。
标签:Campathecin
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CAS No. : 7689-03-4
MCE 站:Camptothecin
产品活性:Camptothecin (Campathecin) 是有效的 DNA拓扑异构酶 I 抑制剂,IC50 值为 679 nM。
研究领域:Cell Cycle/DNA Damage | Antibody-drug Conjugate/ADC Related | Anti-infection | Apoptosis
作用靶点:Topoisomerase | ADC Cytotoxin | Influenza Virus | Fungal | Apoptosis | Antibiotic
In Vitro: [3H]BrCPT labeling of topoisomerase I is enhanced greatly by the presence of DNA; very little labeling of isolated topoisomerase I or isolated DNA occurrs. Even in the presence of DNA, [3H]BrCPT labeling of topoisomerase I is inhibited by camptothecin, suggesting that both CPT and BrCPT bind to the same site on the DNA-topoisomerase I binary complex. With increasing concentrations of camptothecin, closed circular pRR322 DNA (form I) is converted to nicked circular DNA (form 11). This apparent nicking activitv of camptothecin required DNA topoisomerase I.
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更新时间:2024/1/2 10:12:49
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