产品中心

Topotecan Hydrochloride

型号:

产品价格:电议      采购度:1597      原产地:美洲

发布时间:2021/7/16 9:23:50      所属地区:上海 上海市

简要描述:

Topotecan Hydrochloride (SKF 104864A Hydrochloride) 是具有抗癌活性的 拓扑异构酶I 抑制剂。

产品咨询 服务电话:
021-58955995
分享到:

标签:Hycamtin   

产品详情

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。

Topotecan Hydrochloride

CAS No. : 119413-54-6

MCE 站:Topotecan Hydrochloride

产品活性:Topotecan Hydrochloride (SKF 104864A Hydrochloride) 是具有抗癌活性的 拓扑异构酶I 抑制剂。

研究领域:Cell Cycle/DNA Damage  |  Autophagy  |  Apoptosis

作用靶点:Topoisomerase  |  Autophagy  |  Apoptosis

In Vitro: Topotecan Hydrochloride (SKF 104864A Hydrochloride) obviously inhibits proliferation of not only human glioma cells but also glioma stem cells (GSCs) in a dose- and time-dependent manner. According to the IC50 values at 24 h, 3 μM of Topotecan Hydrochloride is selected as the optimal administration concentration. In addition, Topotecan Hydrochloride induces cell cycle arrest in G0/G1 and S phases and promoted apoptosis. Results show that the cell viability is inhibited by Topotecan Hydrochloride in a dose-dependent manner. 2, 20 and 40 μM of Topotecan Hydrochloride obviously inhibits the cell viability compared with the control groups. The IC50 values of Topotecan Hydrochloride at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95±0.24 μM of GSCs-U87. Thus 3 μM of Topotecan Hydrochloride is selected as the optimal administration concentration in the subsequent experiments.

In Vivo: NUB-7 metastatic model, the animals belonging to all the 4 groups are sacrificed after 14 days treatment. Compared with the control, Low dose metronomic (LDM) Topotecan Hydrochloride and TP+Pazopanib (PZ) liver weights are significantly lower in TP+PZ-treated animals, compared with PZ. Microscopic tumors are visible in the livers of mice belonging to all the groups except TP+PZ confirming the ability of Topotecan Hydrochloride+PZ to control liver metastasis. In a previous dose-response study, the daily dose of oral metronomic Topotecan Hydrochloride (0.5, 1.0, and 1.5 mg/kg) causes greater reduction in microvascular density compared with weekly maximum-tolerated dose regimen (7.5 and 15 mg/kg) in an ovarian cancer model, but the mice treated with 1.5 mg/kg daily, oral Topotecan Hydrochloride show decreased food intake, and a lesser antitumor effect.

相关产品:Natural Product Library Plus  |  Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  Natural Product Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  CNS-Penetrant Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Diabetes Related Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  Orally Active Compound Library  |  Traditional Chinese Medicine Monomer Library  |  FDA Approved & Pharmacopeial Drug Library  |  Alkaloids Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  MG-132  |  LY294002  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Paclitaxel  |  Y-27632 dihydrochloride  |  Acetylcysteine  |  Angiotensin II human  |  SP600125  |  5-Fluorouracil  |  Staurosporine  |  Bortezomib  |  Tamoxifen  |  2-Deoxy-D-glucose  |  Gemcitabine  |  Verteporfin  |  Decitabine  |  Actinomycin D  |  Temozolomide  |  BAY 11-7082  |  Etoposide  |  Mitomycin C  |  CCCP  |  DAPT  |  Rotenone  |  Etomoxir  |  Stattic  |  Docetaxel  |  Fulvestrant

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物;
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
•   设有专业的实验中心和严格的质控、验证体系;
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
•   产品的生物活性多经各国客户实验验证;
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果;
•   专业团队跟踪*新的制药及生命科学研究进展,为您提供全球*新的活性化合物;
•   与世界各大制药公司及知名科研机构建立了长期的合作。

1000+ Inhibitors&Agonists 作用于20多条经典信号通路
30+ Screening Libraries 疾病机制研究的高效工具
CCK8 Kit | Cell Counting Kit-8
FDA-Approved 药物筛选库
Inhibitor Cocktails 蛋白酶, 磷酸酶 & 去乙酰化酶
Top Publications Citing Use of MCE
MCE Hotline: 4008203792 | 中国现货 - 全球文献引用 - 高纯度高品质 - 全方位技术支持

更新时间:2024/1/2 10:12:49

留言咨询

  •  
  •  
  •  
  •  
  •  
  •  
  •  
验证码: 点击切换验证码

温馨提示

1.遵守中华人民共和国有关法律、法规,尊重网上道德,承担一切因您的行为而直接或间接引起的法律责任。
2.请您真实的反映产品的情况,不要捏造、诬蔑、造谣。如对产品有任何疑问,也可以留言咨询。
3.未经本站同意,任何人不得利用本留言簿发布个人或团体的具有广告性质的信息或类似言论。

相关新闻

相关产品

联系我们

电话:021-58955995
传真:021-53700325
邮箱:sales@medchemexpress.cn
地址:上海上海

版权所有©MedChemExpress, All Right Reseverd ICP备案号: 总访问量:11021647 管理登录 阿仪网 设计制作,未经允许翻录必究

8

阿仪网推荐收藏该企业网站

联系方式

18019480960
18019480960

工作时间

(24小时)