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Honokiol

CAS No. : 35354-74-6

MCE 站：Honokiol

产品活性：Honokiol是一种具有生物活性的双酚类植物化学物质，靶向多种信号分子，具有有效的抗氧化，抗炎，抗血管生成和抗癌活性。 它抑制 Akt 的活化并增强 ERK1/ERK2 的磷酸化。Honokiol 能透过血脑屏障。

研究领域：PI3K/Akt/mTOR  |  Stem Cell/Wnt  |  MAPK/ERK Pathway  |  Autophagy  |  Anti-infection

作用靶点：Akt  |  ERK  |  Autophagy  |  HCV

In Vitro: Honokiol (0, 12.5, 25 and 50 μM) inhibits the growth of GBM cells and induces apoptosis, with IC₅₀ of appr against 30 μM DBTRG-05MG cell. Honokiol-induced apoptosis of GBM cells is associated with the downregulation of the Rb protein and cleavage of PARP and Bcl-x (S/L). Honokiol (50 μM) increases the level of autophagy markers in GBM cells. Honokiol has anticancer effect, and the IC₅₀ values with MDA-MB-231, MDA-MB-468, and MDA-MB-453 cell lines is 16.99 ± 1.28 μM, 15.94 ± 2.35 μM and 20.11 ±3.13 μM respectively. Honokiol (3, 10 μM) produces significant inhibition on the spheroid number and spheroid sizes in the clonogenic assay. Honokiol (0.1-1.0?μM) specifically inhibits washed human platelet aggregation stimulated by collagen, but not by other agonists. honokiol (0.6 and 1.0?μM) can concentration-dependently inhibit the collagen-induced ATP-release reaction in washed human platelets. Honokiol specifically inhibits platelet aggregation and the phosphorylation of Lyn, PLCγ2, and PKC stimulated with convulxin. Honokiol (5, 10?μM) significantly inhibits convulxin-stimulated MAPKs and Akt activation. Honokiol (10, 20 μM) increases ERK1/2 phosphorylation in a dose-dependent manner depending on CaMK II activation.

In Vivo: Honokiol-NM (40 mg/kg, p.o.) produces superior anticancer effects, and the PCNA, Cyclin D1 and cleaved caspase 3 expressions are 2.12, 1.92 and 1.68-fold significantly altered in this treated group.

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