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Acarbose sulfate

CAS No. : 1221158-13-9

MCE 站：Acarbose sulfate

产品活性：Acarbose (BAY g 5421) sulfate，降糖药，是一种具有口服活性α-葡萄糖苷酶 (alpha-glucosidase) 抑制剂 (IC₅₀=11 nM)。Acarbose sulfate 能增强磺脲类药物或胰岛素的降血糖作用。

研究领域：Metabolic Enzyme/Protease

作用靶点：Glucosidase

In Vitro: Acarbose (1, 2, and 3?μM) dose- and time-dependently inhibits TNF-α-induced VSMC proliferation and migration. Acarbose (1, 2, and 3?μM) dose-dependently decreases β-galactosidase, Ras expression and increased p-AMPK expression in TNF-α pre-treated A7r5 cells.

In Vivo: Acarbose (300 mg/60 kg body weight) decreases the fasting blood glucose, and regulates the glucose tolerance of DM rats without body weight loss. Acarbose significantly suppresses serum IL6 and TNF-α in DM rats. Acarbose (2.5 and 5.0?mg/kg) significantly and dose-dependently decreases the intensity of neointimal IL-6, TNF-α, and iNOS staining, and significantly increases the intensity of neointimal p-AMPK staining. Acarbose (2.5 and 5.0?mg/kg) significantly and dose-dependently decreases neointimal Ras and β-galactosidase expression in HCD-fed rabbits without body weight loss.

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