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产品价格:电议      采购度:1637      原产地:美洲
发布时间:2021/7/16 9:34:16 所属地区:上海 上海市
简要描述:
Artemisinin (Qinghaosu) 是一种倍半萜烯内酯,从青蒿 (Artemisia annua L.) 植物的地上部分分离的抗疟疾药物。Artemisinin 以剂量依赖性方式降低 pAKT 来抑制 AKT 信号通路。Artemisinin 可减少癌细胞的增殖,迁移,侵袭,肿瘤发生和转移,同时 Artemisinin 有神经保护作用。
标签:Qinghaosu
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CAS No. : 63968-64-9
MCE 站:Artemisinin
产品活性:Artemisinin (Qinghaosu) 是一种倍半萜烯内酯,从青蒿 (Artemisia annua L.) 植物的地上部分分离的抗疟疾药物。Artemisinin 以剂量依赖性方式降低 pAKT 来抑制 AKT 信号通路。Artemisinin 可减少癌细胞的增殖,迁移,侵袭,肿瘤发生和转移,同时 Artemisinin 有神经保护作用。
研究领域:Anti-infection | PI3K/Akt/mTOR | Apoptosis
作用靶点:HCV | Parasite | Akt | Ferroptosis
In Vitro: Artemisinin (Qinghaosu) (25 or 50 μM; 24 hours) concentration-dependently suppresses Aβ25-35 induced cytotoxicity in PC12 cells.
Artemisinin (1-100?μM; 24? hours) selectively inhibits cancer cell growth in a dose-dependent manner with IC50 values of 31.30?±?0.73?μM in UMRC-2 cells and 23.97?±?0.92 CAKI-2 cells.
Artemisinin (25, 50?μM; 24?hours) suppresses the phosphorylation of AKT in UMRC-2 and CAKI-2 cells in a dose-dependent manner.
In Vivo: Artemisinin (gavage; 20?mg/kg/day; for two weeks) suppresses UMRC-2 xenograft tumor growth.
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更新时间:2024/1/2 10:12:49
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