MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Doxazosin

CAS No. : 74191-85-8

MCE 站：Doxazosin

产品活性：Doxazosin (UK 33274) 能选择性拮抗突触后的 α1 肾上腺素受体。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Adrenergic Receptor

In Vitro: Doxazosin(UK 33274) is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms. doxazosin may have a direct inhibitory effect on cholesterol synthesis independent of the LDL receptor. The inhibition of cholesterol synthesis by doxazosin may cause cells to compensate by upregulating the LDL receptor, thereby increasing the importation of lipoprotein cholesterol and reducing LDL cholesterol in the medium. Doxazosin monotherapy was effective in eight of 12 patients (66.7%), and combined therapy with a beta-blocker was effective in 11 of 12 patients (91.7%). The mean pulse rate remained constant throughout therapy. Adverse reactions were minor and transient and occurred in only three patients. Urinary and plasma catecholamine levels tended to decrease or remained unchanged during doxazosin therapy.

相关产品：Isoprenaline hydrochloride  |  ICI 118,551 hydrochloride  |  Propranolol hydrochloride  |  Norepinephrine  |  Phenylephrine hydrochloride  |  Pimozide  |  Yohimbine Hydrochloride  |  Olanzapine  |  Prazosin hydrochloride  |  Atenolol  |  Carvedilol  |  CL 316243  |  Amitriptyline hydrochloride  |  Dexmedetomidine hydrochloride  |  L-Epinephrine  |  Metoprolol Succinate  |  YS-49  |  Pindolol  |  Dobutamine hydrochloride  |  Nebivolol hydrochloride  |  Salmeterol  |  Labetalol hydrochloride  |  Perphenazine  |  (S)-Timolol Maleate  |  (±)-Bisoprolol hemifumarate  |  Phentolamine mesylate  |  Terazosin hydrochloride dihydrate  |  Ivabradine hydrochloride

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。