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产品价格:电议      采购度:1602      原产地:美洲
发布时间:2021/7/16 9:43:55 所属地区:上海 上海市
简要描述:
AICAR phosphate (Acadesine phosphate) 是一种腺苷类似物,也是一种 AMPK 激活剂。AICAR phosphate 调节葡萄糖和脂质的代谢,并抑制促炎细胞因子和 iNOS 的产生。AICAR phosphate 也是一种自噬 (autophagy),YAP 和 mitophagy 抑制剂。
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CAS No. : 681006-28-0
MCE 站:AICAR phosphate
产品活性:AICAR phosphate (Acadesine phosphate) 是一种腺苷类似物,也是一种 AMPK 激活剂。AICAR phosphate 调节葡萄糖和脂质的代谢,并抑制促炎细胞因子和 iNOS 的产生。AICAR phosphate 也是一种自噬 (autophagy),YAP 和 mitophagy 抑制剂。
研究领域:Epigenetics | PI3K/Akt/mTOR | Autophagy | Stem Cell/Wnt
作用靶点:AMPK | Autophagy | YAP | Mitophagy
In Vitro: HepG2 cells are treated with various concentrations of AICAR (0.1-1.0 mM) for 12, 24, and 48 h, respectively. The expression level of IR-β significantly decreases with 0.25, 0.5, and 1.0 mM of AICAR at 48 h to 50%, 53%, and 46% of the control, respectively.
In Vivo: Fourteen-week-old male, lean (L; 31.3 g body wt) wild-type andob/ob (O; 59.6 g body wt) mice are injected with the AMP-activated kinase (AMPK) activator AICAR (A) at 0.5 mg*g body wt-1*day-1 or saline control (C) for 14 days. At 24 h after the last injection (including a 12-h fast), all mice are killed, and the plantar flexor complex muscle (gastrocnemius, soleus, and plantaris) is excised for analysis. Muscle mass is lower in OC (159±12 mg) than LC, LA, and OA (176±10, 178±9, and 166±16 mg, respectively) mice, independent of a body weight change. The kidney weight is significantly higher in the untreated group when compared with both the exercise and AICAR (0.5 mg/g body wt) groups. The heart weight is higher in the exercise group than in the other groups, whereas the liver weight is significantly higher in the AICAR-treated group when compared with the exercise and untreated groups.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Epigenetics Compound Library | Kinase Inhibitor Library | PI3K/Akt/mTOR Compound Library | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Natural Product Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Antioxidants Compound Library | Oxygen Sensing Compound Library | Glycolysis Compound Library | Cytoskeleton Compound Library | Alkaloids Library | Anti-Pancreatic Cancer Compound Library | 3-Methyladenine | Doxorubicin hydrochloride | SB 203580 | Deferoxamine mesylate | Dexamethasone | Metformin hydrochloride | Dorsomorphin | U0126-EtOH | Verteporfin | Etoposide | AICAR | Brefeldin A | Resveratrol | Quercetin | Melatonin | Curcumin | Valproic acid | Sunitinib | Tanespimycin | Hemin | Simvastatin | A-769662 | Tripterin | Ivermectin | Aspirin | Kaempferol | Oxidopamine hydrobromide | GSK-690693
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更新时间:2024/1/2 10:12:49
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